欢迎光临 辽宁石油化工大学石油化工学院！
何宇鹏
教授、博士生导师
联系电话：
18242336428
Email:
yupenghe2014@163.com
一、个人基本情况
何宇鹏，男，1979年04月生，教授，博士，博士生导师，现任大连理工大学宁波研究院教授、辽宁石油化工大学兼职教授。辽宁省高等学校创新人才，抚顺市自然科学青年学科带头人；宁波市甬江引才-创新个人、北岸精英创新个人。
二、学习、工作经历
1.学习经历
2006.04-2010.11 德国“马·普”分子生物研究所 化学生物学（专业） 博士
2002.10-2006.07 德国多特蒙德工业大学 化学（专业） 硕士
1997.09-2001.07 辽宁大学 应用化学（专业） 学士
2.工作经历
2024.03-至今 辽宁石油化工大学 石油化工学院（兼职教授）
2023.01-至今 大连理工大学宁波研究院（教授、生物医药团队负责人）
2016.07-2022.12 辽宁石油化工大学 化学化工与环境学部（教授）
2011.07-2016.06 辽宁石油化工大学 化学化工与环境学部（副教授）
三、学术兼职
《Polymers》期刊编委；
宁波化工学会副理事长；
宁波欧美同学会理事；
宁波市江北区侨联常务委员；
《当代化工》杂志青年编委。
四、研究方向
生物医药、精细化工、计算化学、人工智能赋能的医药开发。
五、研究生招生专业
有机化学；应用化学；材料与化工；高分子材料与工程；化学工艺。
六、主要业绩
何宇鹏教授长期致力于药物及有机合成化学、胶体与表界面化学、计算化学等方面的研究。先后入选辽宁省百千万人才工程“百人层次”、辽宁省高等学校创新人才，抚顺市自然科学青年学科带头人；宁波市甬江引才-创新个人、北岸精英创新个人。主持国家自然科学基金两项，科技部军事重大专项子课题一项、中国工程院新冠肺炎疫情防控攻关项目一项，各类省部级课题八项。发表包括Angew. Chem. Int. Ed.、Org.Lett.、Chem.Comm.、Langmiur在内的SCI论文三十余篇。获辽宁省自然科学学术成果二等奖，三次获辽宁省优秀硕士学位论文指导教师。2020年2月疫情爆发伊始，应国务院疫情防控专家组的要求，参与新冠肺炎疫情防控药物一线研发生产。
七、 科研项目
1、宁波甬江引才创新个人项目：抗手足口病毒药物设计、合成及生物评价，2024.01-2029.12，200万元，主持；
2、大连理工大学宁波研究院拔尖人才支持计划项目，2024.07-2027.06，100万元，主持；
3、宁波市自然科学基金重点项目：有机小分子乳化降粘剂的开发及其作用机制的模拟研究，2024.06-2026.05，30万元，主持；
4、宁波北岸精英创新个人项目：肺靶向抗新冠肺炎药物开发，2023.01-2025.12，50万元，主持；
5、中国工程院新冠肺炎疫情防控攻关项目：抗新冠肺炎疫情防控药物研发，2020.02-2020.11，250万元 (马云公益基金会资助)，主持；
6、国家自然科学基金--面上项目：新型芳香酸衍生物凝胶因子的设计、合成及分子动力学模拟研究，2020.01-2023.12；65万元；主持；
7、辽宁省重点研发计划项目：氨基酸小分子絮凝剂在地下水有机污染去除应用中的研究，2019.06-2021.05，30万元；主持；
8、国家自然科学基金--青年项目：联苯环肽类天然产物的全合成和轴手性构象诱导的研究，2013.01-2015.12；25万元；主持；
八、发表论文情况
32. Recyclable Multifunctional PSOGs for Rapid Removal of Wastewater Pollutants (Oily and Dye), Wannian Zhang§, Yingquan Du§, Zhigang Gao, Fang Yu, Yu-Peng He*, Adv. Mater. Interfaces 2025, 12, 2400525. https://doi.org/10.1002/admi.202400525
31. Preparation and Properties of Epoxy Modified Acrylic Polymer, Shiyan Zhou, Jinmei Ma, Jun-Wen Yu, Zhigang Gao, Fei Li, Fenghua Zhang*, Yu-Peng He*, Polymers 2025, 17(3), 380. https://www.mdpi.com/2073-4360/17/3/380
30. Preparation and properties of vinyltriethoxysilane-modified waterborne acrylate resins. Jinmei Ma, Shiyan Zhou, Yaqi Wang, Rong Chen, Shuai Wang, Fenghua Zhang*, Yu-Peng He*, Polymer 2024, 314, 127781.
https://doi.org/10.1016/j.polymer.2024.127781
29. Study of Interfacial Properties of Anionic–Nonionic Surfactants Based on Succinic Acid Derivatives via Molecular Dynamics Simulations and the IGMH Method. Wannian Zhang; Feng Luo; Zhigang Gao; Haizhu Chi; Jinlong Wang; Fang Yu; Yu-Peng He*, Colloids and Interfaces 2024, 8, 41. mdpi.com/2504-5377/8/4/41
28. Experiment and Computational Study on Pd-Catalyzed MIA-Directed Ortho-C—H Alkynlation of Phenylalanine. Fujie Zhang,§ Yu Liang,§ Dong-Hui Liu, Peng-Yu Liu, Liangliang Huang*, Yu-Peng He*, and Fang Yu*, Asian J. Org. Chem. 2024, e202400159. doi.org/10.1002/ajoc.202400159
27. Studies on the properties and molecular dynamics simulations of nonionic surfactants based on succinic acid derivatives. Feng Luo, Wannian Zhang, Fang Yu, Jinlong Wang*, Yu-Peng He*, J Surfact Deterg. 2024, 1-8. doi.org/10.1002/jsde.12778
26. Experiment and Computational Study on Pd-Catalyzed Methoxyiminoacyl-Directed γ-Alkoxylation of Alkylamides, Peng-Yu Liu§, Yi-Min Zhao§, Yuehui Xu, Shuai Wang, Lijuan Song, Qingtao Meng*, Zhiqiang Zhang*, Fang Yu*, and Yu-Peng He*, J. Org. Chem., 2023, 88(20), 14445–14453. 10.1021/acs.joc.3c01460
25. Pd-Catalyzed MIA-Directed Acetoxylation of Benzylamines and Compu-tational Study, Yue-Ning Meng§, Shi-Chen Zhao§, Peng-Yu Liu, Dianwen Hu, Shuai Wang, Yu-Peng He* and Fang Yu*, Eur. J. Org. Chem., 2022, e202200728. 10.1002/ejoc.202200728
24. Methionine-derived organogels as lubricant additives enhance the continuity of the oil film through dynamic self-healing assembly, Kai Wang§, Wannian Zhang§, Na Liu, Dianwen Hu, Fang Yu, Yu-Peng He*, Langmuir, 2022, 38, 11492-11501. 10.1021/acs.langmuir.2c02181
23. Pd-Catalyzed γ‑Acetoxylation of Alkylamides: Structural Influence of Directing Groups, Peng-Yu Liu, Shi-Chen Zhao, Ming-Yuan Zhang, Lijuan Song, Caiping Wang, Fang Yu, Qingtao Meng*, Zhiqiang Zhang*, Yu-Peng He*, J. Org. Chem., 2022, 87, 6378-6386. 10.1021/acs.joc.2c00085
22. Kinetic Resolution of 1,2-Diamines via Organocatalyzed Asymmetric Electrophilic Aminations of Anilines, Jinglei Xie, Zheng Guo, Wei Liu, Dekun Zhang, Yu-Peng He*, Xiaoyu Yang*, Chin. J. Chem., 2022, 40, 1674-1680. 10.1002/cjoc.202200125
21. Enhanced Oil Recovery: QM/MM Based Descriptors for Anionic Surfactant Salt-Resistance, Wannian Zhang, Kai Wang, Caiping Wang, Shanlin Zhao, Zhiqiang Zhang*, Fang Yu*, Yu-Peng He*, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022, 641, 128422. 10.1016/j.colsurfa.
20. Kinetic Resolution of 2,2-Disubstituted Dihydroquinolines through Chiral Phosphoric Acid-Catalyzed C6-Selec tive Asymmetric Halogenations, Chaofan Zhu§, Wei Liu§, Fei Zhao§, Yunrong Chen*, Houchao Tao*, Yu-Peng He*, and Xiaoyu Yang*, Org. Lett., 2021, 23, 4104-4108. 10.1021/acs.orglett.1c00978
19. A Di-Ortho-C-H Arylation of Phenylalanine: A Bimetallic Interaction Between Pd(IV)-Ag(I), QianTao†, Ya-Nan Li†, Wen-Jun Tang, Peng-Yu Liu, Fang Yu, Yu-Peng He*, Tetrahedron Lett., 2021, 153-158. 10.1016/j.tetlet.2021.153158
18. Au(I)-Catalyzed Domino Cyclization of 1,6-Diynes Incorporated with Indole, Guzhou Chen§, Peng-Yu Liu§, Huanhuan Zou§, Jiadong Hu, Xiaowu Fang, Dongyang Xu, Yu-Peng He*, Hongbo Wei*, and Weiqing Xie*, Org. Lett., 2021, 23, 2279-2284. 10.1021/acs.orglett.1c00411
17. Pyromellitic-Based Low Molecular Weight Gelators and Computational Studies of Intermolecular Interactions: A Potential Additive for Lubricant, Wannian Zhang, Zhiqiang Zhang, Shanlin Zhao, Kwon Ho Hong, Ming-Yuan Zhang, Lijuan Song, Fang Yu, Genxiang Luo, and Yu-Peng He*, Langmuir, 2021, 37, 2954-2962. 10.1021/acs.langmuir.0c03625
16. MIA-Directed 2-Pyridione-Enabled Selective Ortho-C-H Arylation of Phenylalanine: A Mechanistic Study, Peng-Peng Niu§, Peng-Yu Liu§, Yue-Ning Meng, Fang Yu, Yu‐Peng He*, J. Org. Chem. 2021, 86,(3), 3096-3106. 10.1021/acs.joc.0c02872
15. Kinetic Resolution of 2‐N‐Acylamido Tertiary Allylic Alcohols: Asymmetric Synthesis of Oxazolines. Yongkai Pan, Qianwen Jiang, Subramani Rajkumar, Chaofan Zhu, Jinglei Xie, Shaoze Yu, Yunrong Chen, Yu‐Peng He*, Xiaoyu Yang*, Adv. Synth. Catal., 2021, 363 (1), 200-207. 10.1002/adsc.202001051
14. Asymmetric Aza-Diels–Alder Reactions of in Situ Generated β,β-Disubstituted α,β-Unsaturated N–H Ketimines Catalyzed by Chiral Phosphoric Acids, Shunlong He, Huanchao Gu, Yu-Peng He*, and Xiaoyu Yang*, Org. Lett., 2020, 22, 5633-5639. 10.1021/acs.orglett.0c01994
13. Visible-light driven synthesis of polycyclic benzo[d][1,3]oxazocine from 2-aminochalcone, Yu-Qi Gao, Yi Hou, Liming Zhu, Junhan Chen, Ruoxin Li, Sheng-Yong Zhang*, Yu-Peng He* and Weiqing Xie*, Chem. Commun., 2020, 56, 6739-6742. 10.1039/D0CC02416C
12. Biosynthetic Hypothesis-Guided Discovery and Total Syntheses of PKS-NRPS Hybrid Metabolites from Endophytic Fungus Periconia Species, Yijun Fan, Dewu Zhang, Xiaoyu Tao, Yuanhao Wang, Jimei Liu, Li Li, Jianyuan Zhao, Liyan Yu, Yu-peng He, Jungui Dai*, and Yefeng Tang*, Org. Lett., 2019, 21, 1794-1798. 10.1021/acs.orglett.9b00371
11. Carboxylate phosphabetaine as a bifunctional organocatalyst for the intramolecular ring opening of oxetane, Dongyang Xu,‡ Hongbo Wei,‡ Yanxia Zhen, Yu-Qi Gao, Ruoxin Li, Xingzhou Li,* Yu-Peng He, Zhong Zhang* and Weiqing Xie*, Org. Chem. Front., 2019, 6, 1681-1685. 10.1039/C9QO00304E
10. A one-pot Protocol for Copper-Mediated Azide-alkyne Cycloaddition Using Alkenyl Triflate Precursors, Yu Chen, Lianchao Liu, Dimin Wu, Yu-Peng He*, Ang Li*, Chin. Chem. Lett., 2019, 30 (1), 269-270. 10.1016/j.cclet.2018.06.001
9. A Concise Total Synthesis of (–)-Hamigeran B and (–)-4-Bromohamigeran B. Bao-Chen Cao,§ Guo-Jie Wu,§ Fang Yu, Yu-Peng He,* and Fu-She Han*, Org. Lett., 2018, 20, 3687-3690. 10.1021/acs.orglett.8b01490
8. Catalytic, Metal-free Sulfonylcyanation of Alkenes via Visible light Organophotoredox Catalysis. Jianfeng Sun,† Peng Li,† Lei Guo, Fang Yu, Yu-Peng He,* and Lingling Chu*, Chem. Comm., 2018, 54, 3162-3165. 10.1039/C8CC00547H
7. Metal-Free Aerobic Oxidative Cyanation of Tertiary Amines: Azobis(isobutyronitrile) (AIBN) as a Sole Cyanide Source. Peng-Yu Liu,§ Chao Zhang,§ Shi-Chen Zhao, Fang Yu, Fei Li, and Yu-Peng He*, J. Org. Chem., 2017, 82, 12786-12790. (§ contributed equally) 10.1021/acs.joc.7b02021
6. Scaleable two-component gelator from phthalic acid derivatives and primary alkyl amines: acid-base interaction in the cooperative assembly. Ting Su, Kwon Ho Hong, Wannian Zhang, Fei Li, Qiang Li, Fang Yu, Genxiang Luo, Honghe Gao and Yu-Peng He*, Soft Matter, 2017, 13, 4066-4073. 10.1039/C7SM00797C
5. Synthesis of Tricyclic Isoxazoles via Sequential [3+2] Dipolar Cycloaddition and Palladium-Catalyzed Intramolecular Arylation Reactions. Dong-Cai Guo, Chao Zhang, Fei Li, Fenghua Zhang, Fang Yu* and Yu-Peng He*, Synthesis, 2017, 49, 1356-1370. 10.1055/s-0036-1588655
4. A Re2O7 catalyzed cycloetherification of monoallylic diols. Xiaolong Wan, Jiadong Hu, Dongyang Xu, Yang Shang, Yanxia Zhen, Chenchen Hu, Fan Xiao, Yu-Peng He,* Yisheng Lai,* Weiqing Xie* Tetrahedron Lett., 2017, 58, 1090-1093. 10.1016/j.tetlet.2017.01.066
3. Rhodium-Catalyzed Regioselective C7-Functionalization of N-Pivaloylindoles. Lanting Xu, Chao Zhang, Yupeng He, Lushi Tan,* and Dawei Ma*, Angew. Chem. Int. Ed., 2016, 55, 321-325. 10.1002/ange.201508117
2. Rhodium(II)-Catalyzed Formal [3+2] Cycloaddition of N-Sulfonyl-1,2,3-triazoles with Isoxazoles: Entry to Polysubstituted-3-Aminopyrroles. Xiaoqiang Lei, Longbo Li, Yu-Peng He,* and Yefeng Tang*, Org. Lett., 2015, 17, 5224-5227. 10.1021/acs.orglett.5b02570
1. Assembly of Indoline-2-carboxylate-Embodied Dipeptides via Pd-Catalyzed C(sp2)-H Bond Direct Functionalization. Yu-Peng He, Chao Zhang, Mengyang Fan, Zhijie Wu, and Dawei Ma*, Org. Lett., 2015, 17, 496-499. 10.1021/ol503514t
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